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Researchers in the IBRC are developing a multifaceted definition of bone quality by employing a variety of techniques to capture the hierarchical and complex contributions of skeletal attributes from micro- to macro-scales. To understand human variation in upper extremity fracture risk during injurious events, we use clinically available imaging techniques to quantify bone morphometric parameters contributing to resistance to fracture and determine their relative influence by subsequently conducting dynamic experimental testing. Investigations into sources of differing inter-individual as well as intra-individual skeletal responses, especially in the radius, to loading include but are not limited to histomorphometric cross-sectional properties, whole bone geometry, structural and material properties, and high resolution quantitative computed tomography (QCT) parameters. All projects maintain an interdisciplinary, hierarchical, and comprehensive approach to understanding bone quality with the goal of advancing upper extremity skeletal injury prediction for all facets of the population.